Physicochemical characteristics of pentamidine-loaded polymethacrylate nanoparticles: implication in the intracellular drug release in Leishmania major infected mice.

@article{Paul1998PhysicochemicalCO,
  title={Physicochemical characteristics of pentamidine-loaded polymethacrylate nanoparticles: implication in the intracellular drug release in Leishmania major infected mice.},
  author={M. Ossou-Nguiet Paul and R{\'e}my Durand and Yves Boulard and Thierry Fusa{\"i} and Consuelo Fern{\'a}ndez and Dani{\`e}le Rivollet and Mich{\'e}le Deniau and Alain Astier},
  journal={Journal of drug targeting},
  year={1998},
  volume={5 6},
  pages={481-90}
}
This work describes the preparation, the physicochemical properties, the tolerance and the intracellular trafficking of pentamidine loaded nanoparticles. Pentamidine was bound to the polymer by ionic interaction. This interaction involved the carboxylic acid functions of methacrylic acid (10% of the polymer) and the amine groups of the drug. Pentamidine… CONTINUE READING