Physicochemical characteristics and in vitro release from oil-based vehicles of peptidomimetics: parenteral depots for intra-articular administration.

@article{Pedersen2011PhysicochemicalCA,
  title={Physicochemical characteristics and in vitro release from oil-based vehicles of peptidomimetics: parenteral depots for intra-articular administration.},
  author={Brian Thoning Pedersen and Jesper Ostergaard and Susan Weng Larsen and Claus Cornett and Michael Ankersen and Claus Larsen},
  journal={Drug development and industrial pharmacy},
  year={2011},
  volume={37 1},
  pages={62-71}
}
RESULTS Basic physicochemical properties including their apparent solubility in aqueous buffer and vegetable oils of a series of 11 peptidomimetics varying with respect to chain length and degree of N-methylation were estimated. It was observed that the compounds in contact with water transformed into sticky, slowly dissolving semisolid materials. Based on… CONTINUE READING