Physicochemical and pharmacokinetic characterization of a spray-dried malotilate emulsion.

  title={Physicochemical and pharmacokinetic characterization of a spray-dried malotilate emulsion.},
  author={Jianjun Zhang and Yuan Gao and Shuai Qian and Xiaoyan Liu and Hui Zu},
  journal={International journal of pharmaceutics},
  volume={414 1-2},
Malotilate (MT) is a hepatoprotective drug administered orally. However, MT was found to be a poorly water-soluble drug with low oral bioavailability. In the present investigation, a novel spray-dried emulsion (SDE) loaded with MT was prepared, and its physicochemical properties were characterized by rheological evaluation, particle size measurement, in vitro release, and surface morphology. The pharmacokinetic study of SDE, in comparison to MT suspension with the pure MT powder homogeneously… CONTINUE READING
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