Physicochemical and microbiological stability studies of extemporaneous antihypertensive pediatric suspensions for hospital use.

@article{Mendes2013PhysicochemicalAM,
  title={Physicochemical and microbiological stability studies of extemporaneous antihypertensive pediatric suspensions for hospital use.},
  author={Cassiana Mendes and Ana Paula Fucci da Costa and Paulo Renato Oliveira and Monika Piazzon Tagliari and Marcos Ant{\^o}nio Segatto Silva},
  journal={Pharmaceutical development and technology},
  year={2013},
  volume={18 4},
  pages={813-20}
}
Extemporaneous suspensions of the antihypertensive agents furosemide, spironolactone and hydrochlorothiazide for pediatric use have been prepared at University Hospital (Federal University of Santa Catarina - Brazil). The aim of this work was to investigate the physicochemical and microbiological stability of these suspensions over the estimated shelf-life period of seven days and, if necessary, to optimize the formulations by improving the chemical stability. The pediatric suspensions were… CONTINUE READING