Physicochemical and metabolic basis for the differing neurotoxicity of the pyrrolizidine alkaloids, trichodesmine and monocrotaline

@article{Huxtable1996PhysicochemicalAM,
  title={Physicochemical and metabolic basis for the differing neurotoxicity of the pyrrolizidine alkaloids, trichodesmine and monocrotaline},
  author={Ryan J. Huxtable and Chien Chun Yan and Stacie Lynn. Wild and Simon Maxwell and Raymond D. Cooper},
  journal={Neurochemical Research},
  year={1996},
  volume={21},
  pages={141-146}
}
Monocrotaline and trichodesmine are structurally closely related pyrrolizidine alkaloids (PAs) exhibiting different extrahepatic toxicities, trichodesmine being neurotoxic (LD50 57 μmol/kg) and monocrotaline pneumotoxic (LD50 335 μmol/kg). We have compared certain physicochemical properties and metabolic activities of these two PAs in order to understand the quantitative and qualitative differences in toxicity. Both PAs were metabolized in the isolated, perfused rat liver to highly reactive… CONTINUE READING
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