Physicochemical and functional changes in human leukemic cell line HL-60.

  title={Physicochemical and functional changes in human leukemic cell line HL-60.},
  author={Olle Stendahl and Claes Dahlgren and Jan Hed},
  journal={Journal of cellular physiology},
  volume={112 2},
The recently established human promyelocytic cell line HL-60 was induced to differentiate in the present of DMSO. During this process, physicochemical, and functional changes were detected simultaneously. After exposure to DMSO for more than 1 day, the cell volume decreased and the tendency for hydrophobic interaction increased. Using a hydrophobic two-phase system in counter current distribution fashion, it was then possible to separate more mature metamyelocytes and segmented granulocytes… CONTINUE READING

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