Physicochemical and cell biological characterization of PMMA bone cements modified with additives to increase bioactivity.

@article{WolfBrandstetter2013PhysicochemicalAC,
  title={Physicochemical and cell biological characterization of PMMA bone cements modified with additives to increase bioactivity.},
  author={Cornelia Wolf-Brandstetter and Sophie Roessler and Sandra Storch and Ute Hempel and Uwe Gbureck and Berthold Nies and Susanne Bierbaum and Dieter Scharnweber},
  journal={Journal of biomedical materials research. Part B, Applied biomaterials},
  year={2013},
  volume={101 4},
  pages={
          599-609
        }
}
Polymethylmethacrylate (PMMA) bone cement is the most widely used material in surgery to fix joint replacements in the bone. In this study, we propose a new approach to generate bioactive PMMA surfaces directly at the site of implantation by adding the amphiphilic molecule phosphorylated 2-hydroxyethylmethacrylate (HEMA-P) to commercial PMMA bone cement, both with or without addition of 1-5% soluble calcium and carbonate salts. The setting behavior as well as the mechanical properties, the… CONTINUE READING

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Performance of bioactive PMMA-based bone cement under load-bearing conditions: an in vivo evaluation and FE simulation

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