Physicochemical and cell-based approach for early screening of phospholipidosis-inducing potential.

  title={Physicochemical and cell-based approach for early screening of phospholipidosis-inducing potential.},
  author={Kaori Tomizawa and Kiyohiko Sugano and Hiroshi Y Yamada and Ikuo Horii},
  journal={The Journal of toxicological sciences},
  volume={31 4},
Some of the principal requisites of toxicity screening methods in drug discovery are their ease to perform and high throughput, as well as the possibility to predict the occurrence of clinical events. Phospholipidosis is one of the toxicities often induced by potential drugs. Several physicochemical methods for the prediction of phospholipidosis have been reported. The purpose of the present study was to examine the predictability of methods based on lipophilicity and charge parameters. We… CONTINUE READING
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