Physicochemical and biological characterization of ceramide-containing liposomes: paving the way to ceramide therapeutic application.


Ceramides mediate antiproliferative responses, and it has been proposed that increasing the level of ceramides in cancer cells may have a therapeutic antitumor effect. However, ceramides, because of their high "packing parameter" (PP), do not form lipid assemblies that can be dispersed in a form suitable for intravenous administration. We found that… (More)
DOI: 10.1021/la800207z


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