Physicochemical and biological aspects of macrophage-mediated drug targeting in anti-microbial therapy.

@article{Kunjachan2012PhysicochemicalAB,
  title={Physicochemical and biological aspects of macrophage-mediated drug targeting in anti-microbial therapy.},
  author={Sijumon Kunjachan and Sajan Jose and Cinu A Thomas and Emil Joseph and Fabian Kiessling and Twan Lammers},
  journal={Fundamental & clinical pharmacology},
  year={2012},
  volume={26 1},
  pages={63-71}
}
Macrophages are important drug targets as they mediate a wide variety of infectious diseases. Visceral leishmaniasis (VL), schistosomiasis, brucellosis, and salmonellosis are some of the well-known infectious diseases in which macrophages play a prominent pathophysiological role. For instance, VL parasites exclusively house in the macrophages of liver and spleen. They are resistant to lysosomal degradation by unknown mechanisms, they survive and thrive safely within macrophages, they multiply… CONTINUE READING