Corpus ID: 43715666

Physico-chemical properties and biological activities of erythromycin nalidixate.

@article{Goswami1995PhysicochemicalPA,
  title={Physico-chemical properties and biological activities of erythromycin nalidixate.},
  author={B. Goswami and P. K. Manna and S. Basu},
  journal={Arzneimittel-Forschung},
  year={1995},
  volume={45 7},
  pages={
          813-4
        }
}
Erythromycin nalidixate was prepared by combining nalidixic acid with erythromycin base. Thin-layer chromatographic studies and infrared absorption spectrum confirmed homogeneity of the new salt. The salt is very soluble in nonpolar solvent and freely soluble in polar solvent. The salt is quite stable at room temperature (30 +/- 1 degrees C). The antimicrobially active dose of the salt was found to be 820 micrograms/mg. Serum protein binding amounted to 85% and was reversible. LD50 in mice was… Expand