Physico-chemical correlates of alcohol intoxication

  title={Physico-chemical correlates of alcohol intoxication},
  author={M McCreery and Walter A. Hunt},
Hypothermic effects of a homologous series of short-chain alcohols in rats.
There was a high inverse correlation between the hypothermic dose of an alcohol and its lipid solubility, and the potency of ancohol was strongly correlated with its Pm/b, which suggests that the membrane disordering theory of narcosis may also be used to explain the Hypothermic action of alcohols.
Short-term immunological effects of non-ethanolic short-chain alcohols.
Neurotransmitter-Gated Ion Channels as Molecular Sites of Alcohol Action
The mechanism of alcohol action in the nervous system has long been a subject of great interest, and a correlation between the anesthetic potencies of different alcohols and their partition between olive oil and water led to the idea that alcohols exert their anesthetic action on the hydrophobic lipid bilayer membrane of cells.
Discriminative stimulus properties of toluene in the mouse.
Cellular and molecular physiology of alcohol actions in the nervous system.
  • F. F. Weight
  • Medicine, Biology
    International review of neurobiology
  • 1992
CNS depressant effects of volatile organic solvents
A selective imidazobenzodiazepine antagonist of ethanol in the rat.
The identification of a selective benzodiazepine antagonist of ethanol-stimulated 36Cl- uptake in vitro that blocks the anxiolytic and intoxicating actions ofanol suggests that many of the neuropharmacologic actions of ethanol may be mediated via central GABA receptors.
Low-level hyperbaric exposure antagonizes locomotor effects of ethanol and n-propanol but not morphine in C57BL mice.
Exposure to 12 ATA heliox antagonizes the behavioral effects of intoxicant-anesthetic drugs like ethanol and n-propanol, but does not antagonize the effects of drugs like morphine, which act via more direct mechanisms.


Unspecific drug action. The effects of a homologous series of primary alcohols.
  • H. Rang
  • Medicine
    British journal of pharmacology and chemotherapy
  • 1960
Ferguson's principle of using thermodynamic activity instead of concentration as an index of activity was applied to the present results and it was found that the log-concentration action curves of alcohols on all four systems were straight over most of their range and, for any one system, parallel throughout the series.
The effects of aliphatic alcohols on the biophysical and biochemical correlates of membrane function.
  • W. A. Hunt
  • Biology
    Advances in experimental medicine and biology
  • 1975
Studies of alcohol-membrane interactions have employed the use of artificial and nonneural membranes, invertebrate neurons for electrophysiological measurements and brain tissue for studying ion fluxes and enzymatic activities, but for the most part these studies have been inclusive because high concentrations of alcohols were needed to elicit any effect.
Effects of Alcohol on the Neuron
It should be made clear at once that the nature of the ensuing discussion is deliberately limited. Consideration of the effects of alcohols on cerebral neurons (or stated another way, cerebral
The Use of Chemical Potentials as Indices of Toxicity
A number of investigation have been published in which attempts are made to correlate the chemical or physical properties of substances with the intensity of their toxic action. Among these may be
The membrane actions of anesthetics and tranquilizers.
A diagrammatic summary of the membrane actions of anesthetics and tran-quilizers is shown, and the membrane fluidization may explain the enhanced neurosecretion of membrane-bound materials, by a mechanism of membranes-membrane fusion.
Effects of lower alcohols on potassium transport and microsomal adenosine-triphosphatase activity of rat cerebral cortex.
It is suggested that inhibition of cation transport is an important, but not a primary, mechanism in the production of central nervous depression by alcohols and other substances.
Absorption, Diffusion, Distribution, and Elimination of Ethanol: Effects on Biological Membranes
The basic facts of alcohol absorption, distribution, metabolism, and excretion were described clearly many years ago by Nicloux and Grehant, but later work by a multitude of investigators has clarified the mechanisms, the quantitative relationships, and the influence of various physiological, pathological, and pharmacological factors upon these processes.