Physico-chemical correlates of alcohol intoxication

@article{McCreery1978PhysicochemicalCO,
  title={Physico-chemical correlates of alcohol intoxication},
  author={M. McCreery and W. A. Hunt},
  journal={Neuropharmacology},
  year={1978},
  volume={17},
  pages={451-461}
}
In previous attempts to determine the molecular basis of action of alcohols and other depressants, experiments have generally been performed in vitro with artificial systems or were concerned only with narcotizing properties. The main medical concern with alcohols, especially ethanol, is their ability to induce intoxication, involving impairment of gait, slowed reflexes, muscular flaccidity and impaired judgment. No attempts have been made previously to gain an estimate of some of the molecular… Expand
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148 Citations
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The effects of alcohols and diols at the nicotinic acetylcholine receptor of the neuromuscular junction
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After dose-response curves were carried out in high doses of ethanol and propanediol, the number of receptors was found to be permanently reduced and reversible denaturation could account for some of the reversible blocking effects caused by such drugs. Expand
Short-term immunological effects of non-ethanolic short-chain alcohols.
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The general mechanisms of short-chain alcohol-induced biological dysregulation are examined and a tentative model is provided to explain the molecular events that underlie the immunological dysfunction produced by methanol and isopropanol. Expand
Neurotransmitter-Gated Ion Channels as Molecular Sites of Alcohol Action
The mechanism of alcohol action in the nervous system has long been a subject of great interest. Almost a century ago, two German scientists, Overton (1896; 1901) and Meyer (1899; 1901), found a… Expand
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Different patterns of changes were found in the two groups for plasma concentrations of beta-endorphin and adrenocorticotropic hormone in drinkers, whereas in nondrinkers both concentrations decreased, the declines being especially notable 15, 30, and 45 min after ingestion. Expand
Discriminative stimulus properties of toluene in the mouse.
TLDR
Results show that the effects of injected toluene can be established as a discriminative stimulus in mice, and that these stimulus effects are independent of route of administration, and suggest that toLUene produces an acute intoxication like that of other classic CNS depressants. Expand
Cellular and molecular physiology of alcohol actions in the nervous system.
  • F. F. Weight
  • Chemistry, Medicine
  • International review of neurobiology
  • 1992
TLDR
This chapter focuses on the acute neuronal actions of alcohol, as detected by neurophysiological techniques, and discusses the possible cellular and molecular basis of alcohol's behavioral actions. Expand
CNS depressant effects of volatile organic solvents
TLDR
The possibility that selected solvents can have acute effects similar to those of depressant drugs may shed light on the nature of their acute behavioral toxicology and on their abuse. Expand
A selective imidazobenzodiazepine antagonist of ethanol in the rat.
TLDR
The identification of a selective benzodiazepine antagonist of ethanol-stimulated 36Cl- uptake in vitro that blocks the anxiolytic and intoxicating actions ofanol suggests that many of the neuropharmacologic actions of ethanol may be mediated via central GABA receptors. Expand
Low-level hyperbaric exposure antagonizes locomotor effects of ethanol and n-propanol but not morphine in C57BL mice.
TLDR
Exposure to 12 ATA heliox antagonizes the behavioral effects of intoxicant-anesthetic drugs like ethanol and n-propanol, but does not antagonize the effects of drugs like morphine, which act via more direct mechanisms. Expand
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