Physico-chemical correlates of alcohol intoxication

@article{McCreery1978PhysicochemicalCO,
  title={Physico-chemical correlates of alcohol intoxication},
  author={M McCreery and Walter A. Hunt},
  journal={Neuropharmacology},
  year={1978},
  volume={17},
  pages={451-461}
}
Hypothermic effects of a homologous series of short-chain alcohols in rats.
TLDR
There was a high inverse correlation between the hypothermic dose of an alcohol and its lipid solubility, and the potency of ancohol was strongly correlated with its Pm/b, which suggests that the membrane disordering theory of narcosis may also be used to explain the Hypothermic action of alcohols.
Short-term immunological effects of non-ethanolic short-chain alcohols.
Neurotransmitter-Gated Ion Channels as Molecular Sites of Alcohol Action
TLDR
The mechanism of alcohol action in the nervous system has long been a subject of great interest, and a correlation between the anesthetic potencies of different alcohols and their partition between olive oil and water led to the idea that alcohols exert their anesthetic action on the hydrophobic lipid bilayer membrane of cells.
Discriminative stimulus properties of toluene in the mouse.
Cellular and molecular physiology of alcohol actions in the nervous system.
  • F. F. Weight
  • Medicine, Biology
    International review of neurobiology
  • 1992
CNS depressant effects of volatile organic solvents
A selective imidazobenzodiazepine antagonist of ethanol in the rat.
TLDR
The identification of a selective benzodiazepine antagonist of ethanol-stimulated 36Cl- uptake in vitro that blocks the anxiolytic and intoxicating actions ofanol suggests that many of the neuropharmacologic actions of ethanol may be mediated via central GABA receptors.
Low-level hyperbaric exposure antagonizes locomotor effects of ethanol and n-propanol but not morphine in C57BL mice.
TLDR
Exposure to 12 ATA heliox antagonizes the behavioral effects of intoxicant-anesthetic drugs like ethanol and n-propanol, but does not antagonize the effects of drugs like morphine, which act via more direct mechanisms.
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TLDR
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