Physical trapping of HIV-1 synaptic complex by different structural classes of integrase strand transfer inhibitors.

@article{Pandey2010PhysicalTO,
  title={Physical trapping of HIV-1 synaptic complex by different structural classes of integrase strand transfer inhibitors.},
  author={Krishan K. Pandey and Sibes Bera and Ajaykumar C. Vora and Duane P. Grandgenett},
  journal={Biochemistry},
  year={2010},
  volume={49 38},
  pages={8376-87}
}
Raltegravir is an FDA approved inhibitor directed against human immunodeficiency virus type 1 (HIV-1) integrase (IN). In this study, we investigated the mechanisms associated with multiple strand transfer inhibitors capable of inhibiting concerted integration by HIV-1 IN. The results show raltegravir, elvitegravir, MK-2048, RDS 1997, and RDS 2197 all appear to encompass a common inhibitory mechanism by modifying IN-viral DNA interactions. These structurally different inhibitors bind to and… CONTINUE READING
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