Physical studies of the interactions of acetylcholine chloride with membrane constituents.

  title={Physical studies of the interactions of acetylcholine chloride with membrane constituents.},
  author={Helmut Hauser and Michael C Phillips and Robert Marchbanks},
  journal={The Biochemical journal},
  volume={120 2},
The binding of acetylcholine to pure lipids, and lipids, proteins and lipoproteins extracted from synaptic membranes, was investigated by monolayer and n.m.r. techniques. No specific binding of acetylcholine could be detected at the concentration used, although its muscarinic and nicotinic antagonists [atropine and (+)-tubocurarine respectively] could be shown to interact with the membrane components. It is concluded that the binding of the nicotinic and muscarinic antagonists of acetylcholine… CONTINUE READING
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