Physical state and biological activity of lipopolysaccharides. Toxicity and immunogenicity of the lipid A component.

@article{Galanos1975PhysicalSA,
  title={Physical state and biological activity of lipopolysaccharides. Toxicity and immunogenicity of the lipid A component.},
  author={Christopher Galanos},
  journal={Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie},
  year={1975},
  volume={149 2-4},
  pages={214-29}
}
Bacterial lipopolysaccharides are negatively charged macromolecules due to the presence of phosphate, pyrophosphate and carboxyl groups. When isolated from bacteria, they are obtained in salt form with metal cations and basic amines. Removal of these ionically bound substances by electrodialysis leads to acidic lipopolysaccharides which on neutralizing with different bases, preparations are obtained which show distinct differences in their physico-chemical properties and in their biological… CONTINUE READING

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