Physical stability of cholesterol derivatives combined with liposomes and their in vitro behavior

  • Bin Yang, Sheng-Yong Geng, Jin-Ye Wang
  • Published 2013 in EMBC

Abstract

The purpose of this study was to investigate the physical stability and drug release of two cholesterol derivatives (4-cholesterocarbonyl-4'-(N,N,N-triethylamine butyloxyl bromide, CTBBA, and 4-cholesterocarbonyl-4'-(N,N'-diethylamino-butyloxy, CDBA), when combined with doxorubicin (DOX)-loaded liposomes in vitro. CTBBA-liposome revealed a positive charge at a pH between 3 and 10, as indicated by the ζ-potential. DOX-encapsulated CTBBA-liposomes possessed better physical stability both in PBS and in fetal bovine serum (FBS) added to PBS.

DOI: 10.1109/EMBC.2013.6610450

Cite this paper

@article{Yang2013PhysicalSO, title={Physical stability of cholesterol derivatives combined with liposomes and their in vitro behavior}, author={Bin Yang and Sheng-Yong Geng and Jin-Ye Wang}, journal={Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference}, year={2013}, volume={2013}, pages={4114-7} }