Physical stability and solubility advantage from amorphous celecoxib: the role of thermodynamic quantities and molecular mobility.

@article{Gupta2004PhysicalSA,
  title={Physical stability and solubility advantage from amorphous celecoxib: the role of thermodynamic quantities and molecular mobility.},
  author={Piyush B. Gupta and Garima Chawla and Arvind K Bansal},
  journal={Molecular pharmaceutics},
  year={2004},
  volume={1 6},
  pages={406-13}
}
Glassy pharmaceuticals, characterized by excess thermodynamic properties, are theoretically more soluble than their crystalline counterparts. The practical solubility advantage of the amorphous form of celecoxib (CEL) is lost due to its proclivity to lose energy and undergo solvent-mediated devitrification. Theoretical assessment of solubility advantage using differences in isobaric heat capacities (Cp) revealed a 7-21-fold enhancement in the solubility of the amorphous form over that of the… CONTINUE READING

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