Physical modulation of intracellular signaling processes by locational regulation.

  title={Physical modulation of intracellular signaling processes by locational regulation.},
  author={Jason M. Haugh and Douglas A. Lauffenburger},
  journal={Biophysical journal},
  volume={72 5},
Recent observations in the field of signal transduction suggest that where a protein is located within a cell can be as important as its activity measured in solution for activation of its downstream pathway. The physical organization of the cell can provide an additional layer of control upon the chemical reaction networks that govern ultimately perceived signals. Using the cytosol and plasma membrane as relevant compartmental distinctions, we analyze the effect of relocation on the rate of… CONTINUE READING

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