Physical modeling of animal cell damage by hydrodynamic forces in suspension cultures.

@article{Lu1992PhysicalMO,
  title={Physical modeling of animal cell damage by hydrodynamic forces in suspension cultures.},
  author={G Z Lu and Murray R. Gray and B. G. J. Thompson},
  journal={Biotechnology and bioengineering},
  year={1992},
  volume={40 10},
  pages={1277-81}
}
Physical damage of animal cells in suspension culture, due to stirring and sparging, is coupled with complex metabolic responses. Nylon microcapsules, therefore, were used as a physical model to study the mechanisms of damage in a stirred bioreactor and in a bubble column. Microcapsule breaskage folowed first-order kinetices in all experiments Entrainment of bubbles into the liquid phase in the stirred bioreactor gave more microcapsule breakage. In the bubble column, the bubble bursting zone at… CONTINUE READING

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