Physical model of the immune response of bacteria against bacteriophage through the adaptive CRISPR-Cas immune system

@article{Han2013PhysicalMO,
  title={Physical model of the immune response of bacteria against bacteriophage through the adaptive CRISPR-Cas immune system},
  author={Pu Han and Liang Ren Niestemski and Jeffrey E. Barrick and Michael W. Deem},
  journal={Physical Biology},
  year={2013},
  volume={10}
}
Bacteria and archaea have evolved an adaptive, heritable immune system that recognizes and protects against viruses or plasmids. This system, known as the CRISPR-Cas system, allows the host to recognize and incorporate short foreign DNA or RNA sequences, called ‘spacers’ into its CRISPR system. Spacers in the CRISPR system provide a record of the history of bacteria and phage coevolution. We use a physical model to study the dynamics of this coevolution as it evolves stochastically over time… 

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