Physical methods to quantify small antibiotic molecules uptake into Gram-negative bacteria.

@article{Winterhalter2015PhysicalMT,
  title={Physical methods to quantify small antibiotic molecules uptake into Gram-negative bacteria.},
  author={Mathias Winterhalter and Matteo Ceccarelli},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2015},
  volume={95 Pt A},
  pages={
          63-7
        }
}
  • Mathias Winterhalter, Matteo Ceccarelli
  • Published in
    European journal of…
    2015
  • Chemistry, Medicine
  • The development of antibiotics against Gram-negative bacteria is a challenge: any active compound must cross the outer cell envelope composed of a hydrophilic highly charged lipopolysaccharide layer followed by a tight hydrophobic layer containing water filled gates called porins to reach the hydrophilic periplasmic space and depending on the target with the further need to cross the hydrophobic inner membrane. In addition to a possible rapid enzymatic deactivation efflux pumps shuffle… CONTINUE READING

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