Physical mapping of the paralysis-inducing determinant of a wild mouse ecotropic neurotropic retrovirus.

@article{DesGroseillers1984PhysicalMO,
  title={Physical mapping of the paralysis-inducing determinant of a wild mouse ecotropic neurotropic retrovirus.},
  author={L DesGroseillers and M Barrette and Paul Jolicoeur},
  journal={Journal of virology},
  year={1984},
  volume={52 2},
  pages={
          356-63
        }
}
We have recently shown that a molecularly cloned ecotropic retrovirus, initially isolated from the brain of a paralyzed wild mouse, retained the ability to induce hind limb paralysis when inoculated into susceptible mice (Jolicoeur et al., J. Virol. 45:1159-1163, 1983). To map the viral DNA sequences encoding the determinant of paralysis, we constructed chimeric viral DNA genomes in vitro between parental cloned infectious viral DNA genomes from this neurotropic murine leukemia virus (MuLV) and… CONTINUE READING

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