Physical mapping of chromosomes using unique probes

@article{Alizadeh1994PhysicalMO,
  title={Physical mapping of chromosomes using unique probes},
  author={Farid Alizadeh and Richard M. Karp and Deborah K. Weisser and Geoffrey Zweig},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  year={1994},
  volume={2 2},
  pages={
          159-84
        }
}
  • F. Alizadeh, R. Karp, G. Zweig
  • Published 23 January 1994
  • Computer Science
  • Journal of computational biology : a journal of computational molecular cell biology
The goal of physical mapping of the genome is to reconstruct a strand of DNA given a collection of overlapping fragments, or clones, from the strand. We present several algorithms to infer how the clones overlap, given data about each clone. We focus on data used to map human chromosomes 21 and Y, in which relatively short substrings, or probes, are extracted from the ends of clones. The substrings are long enough to be unique with high probability. The data we are given is an incidence matrix… 
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References

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TLDR
The program ODS is very general in the types of data that can be utilized for chromosome reconstruction, such as hybridized synthetic oligonucleotides, restriction endonuclease recognition sites or single copy landmarks, can be used for analysis.
Optimized strategies for sequence-tagged-site selection in genome mapping.
TLDR
The results of these simulations suggest that a nonrandom STS strategy that uses paired probes requires one-third to one-fourth as many STS assays as are required in random and nonpaired approaches, and also results in a map that has both greater genome coverage and a larger average contig size.
The human Y chromosome: overlapping DNA clones spanning the euchromatic region.
TLDR
The human Y chromosome was physically mapped by assembling 196 recombinant DNA clones, each containing a segment of the chromosome, into a single overlapping array, revealing that Y-chromosomal genes are scattered among a patchwork of X-homologous, Y-specific repetitive, and single-copy DNA sequences.
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TLDR
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TLDR
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TLDR
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TLDR
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