Physical mapping of chromosome 21.

@article{Patterson1993PhysicalMO,
  title={Physical mapping of chromosome 21.},
  author={David Patterson and Zohra Rahmani and Deborah D. Donaldson and Kathleen Gardiner and Carol M Jones},
  journal={Progress in clinical and biological research},
  year={1993},
  volume={384},
  pages={33-50}
}
Chromosome 21, the smallest human chromosome, has been the subject of intense study because it is the chromosome which, when present in an extra copy, leads to Down Syndrome. Moreover, there are genes important for several human genetic disorders on this chromosome, and a significant number of individuals with aneuploidies of regions of the chromosome have been identified. A high fidelity, high resolution physical map of chromosome 21 will be of immense value in generating an accurate genotype… CONTINUE READING

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