Physical limits of cells and proteomes.

@article{Dill2011PhysicalLO,
  title={Physical limits of cells and proteomes.},
  author={Ken A. Dill and Kingshuk Ghosh and Jeremy D Schmit},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 44},
  pages={17876-82}
}
What are the physical limits to cell behavior? Often, the physical limitations can be dominated by the proteome, the cell's complement of proteins. We combine known protein sizes, stabilities, and rates of folding and diffusion, with the known protein-length distributions P(N) of proteomes (Escherichia coli, yeast, and worm), to formulate distributions and scaling relationships in order to address questions of cell physics. Why do mesophilic cells die around 50 °C? How can the maximal growth… CONTINUE READING
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