Physical interactions between Mcm10, DNA, and DNA polymerase alpha.

@article{Warren2009PhysicalIB,
  title={Physical interactions between Mcm10, DNA, and DNA polymerase alpha.},
  author={Eric Mason Warren and Hao Huang and Ellen M. Fanning and Walter J Chazin and Brandt F Eichman},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 36},
  pages={
          24662-72
        }
}
Mcm10 is an essential eukaryotic protein required for the initiation and elongation phases of chromosomal replication. Specifically, Mcm10 is required for the association of several replication proteins, including DNA polymerase alpha (pol alpha), with chromatin. We showed previously that the internal (ID) and C-terminal (CTD) domains of Mcm10 physically interact with both single-stranded (ss) DNA and the catalytic p180 subunit of pol alpha. However, the mechanism by which Mcm10 interacts with… CONTINUE READING
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