Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic.

@article{Bnichou1994PhysicalIO,
  title={Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic.},
  author={Serge B{\'e}nichou and Morgane Bomsel and M. Bodeus and H. Mortimer Durand and Monique Dout{\'e} and François Letourneur and Jacques H. Camonis and Richard Benarous},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 48},
  pages={30073-6}
}
Nef is a 27-kDa myristylated protein conserved in most human immunodeficiency virus (HIV)-1, HIV-2, and simian immunodeficiency virus isolates. Simian immunodeficiency virus Nef is required in macaques for both high viral load and full pathological effects. Nef down-regulates the cell surface expression of CD4 by a post-translational mechanism that is not yet fully elucidated. We have used the yeast two-hybrid system to identify cellular proteins that interact with Nef. A cDNA was isolated… CONTINUE READING
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