Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex.

@article{Chailleux2010PhysicalIB,
  title={Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex.},
  author={Catherine Chailleux and Sandrine Tyteca and Christophe Papin and François Boudsocq and Nadine Puget and C{\'e}line Courilleau and Mikha{\"i}l Grigoriev and Yvan Canitrot and Didier Trouche},
  journal={The Biochemical journal},
  year={2010},
  volume={426 3},
  pages={365-71}
}
Chromatin modifications and chromatin-modifying enzymes are believed to play a major role in the process of DNA repair. The histone acetyl transferase Tip60 is physically recruited to DNA DSBs (double-strand breaks) where it mediates histone acetylation. In the present study, we show, using a reporter system in mammalian cells, that Tip60 expression is required for homology-driven repair, strongly suggesting that Tip60 participates in DNA DSB repair through homologous recombination. Moreover… CONTINUE READING

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