Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells.

@article{Bandyopadhyay1998PhysicalIB,
  title={Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells.},
  author={Debdutta Bandyopadhyay and Mahitosh Mandal and Lynda Adam and John Mendelsohn and Rajiv Kumar},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 3},
  pages={1568-73}
}
Binding of extracellular ligands to epidermal growth factor receptors (EGFR) activate signal transduction pathways associated with cell proliferation, and these events are inhibited by monoclonal antibodies against EGFR. Since efficient DNA repair in actively growing cells may require growth factor signaling, it was of interest to explore any linkage between EGFR-mediated signaling and DNA-dependent protein kinase (DNA-PK), an enzyme believed to be involved in repairing double strand breaks and… CONTINUE READING

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