Physical incorporation of a single-stranded oligodeoxynucleotide during targeted repair of a human chromosomal locus.

@article{Radecke2006PhysicalIO,
  title={Physical incorporation of a single-stranded oligodeoxynucleotide during targeted repair of a human chromosomal locus.},
  author={Sarah Radecke and Frank Radecke and Ingrid Peter and Klaus Schwarz},
  journal={The journal of gene medicine},
  year={2006},
  volume={8 2},
  pages={217-28}
}
BACKGROUND Targeted gene repair is an attractive method to correct point-mutated genes at their natural chromosomal sites, but it is still rather inefficient. As revealed by earlier studies, successful gene correction requires a productive interaction of the repair molecule with the target locus. The work here set out to investigate whether DNA repair, e.g., mismatch repair, or a direct incorporation of the correction molecule follows as the step upon the initial interaction. METHODS Single… CONTINUE READING

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