Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study.

@article{Smith2009PhysicalII,
  title={Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study.},
  author={Caren E. Smith and Donna K Arnett and Michael Tsai and Chao-Qiang Lai and Laurence D. Parnell and Jian Shen and Mart{\'i}n Laclaustra and Mireia Junyent and Jos{\'e} M. Ordov{\'a}s},
  journal={Atherosclerosis},
  year={2009},
  volume={206 2},
  pages={500-4}
}
BACKGROUND Plasma high density lipoprotein (HDL) cholesterol (HDL-C) concentration is highly heritable but is also modifiable by environmental factors including physical activity. HDL-C response to exercise varies among individuals, and this variability may be associated with genetic polymorphisms in the key regulators of HDL metabolism including endothelial lipase (LIPG). METHODS We examined associations between variants LIPG T111I (rs2000813) and LIPG i24582 (rs6507931), HDL and television… CONTINUE READING