Physical fine mapping of genes underlying X-linked deafness and non fra(X)-X-linked mental retardation at Xq21

@article{Bach1992PhysicalFM,
  title={Physical fine mapping of genes underlying X-linked deafness and non fra(X)-X-linked mental retardation at Xq21},
  author={Ivo Bach and David Robinson and Nick Thomas and H. -H. Ropers and Frans P. M. Cremers},
  journal={Human Genetics},
  year={1992},
  volume={89},
  pages={620-624}
}
Linkage studies and cytogenetically visible deletions associated with nonspecific X-linked mental retardation (XLMR) and a specific form of deafness (DFN3) have indicated that the genes responsible for these disorders are located at Xq21. Using DNA probes from this region, we have studied several overlapping deletions spanning different parts of Xq21. This has enabled us to assign the DFN3 gene and a gene for nonspecific XLMR to an interval that encompasses the locus DXS232 and that is flanked… CONTINUE READING

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