Physical exercise and environment exploration affect synaptogenesis in adult-generated neurons in the rat dentate gyrus: Possible role of BDNF

  title={Physical exercise and environment exploration affect synaptogenesis in adult-generated neurons in the rat dentate gyrus: Possible role of BDNF},
  author={Patrizia Ambrogini and Davide Lattanzi and Stefano Ciuffoli and Michele Betti and Mirco Fanelli and Riccardo Cuppini},
  journal={Brain Research},
Learning-dependent LTP and synaptic ultrastructural modification after physical exercise in rats with middle cerebral artery occlusion : relevance for learning and memory
There is a widespread assumption that the improvement of learning and memory in MACO rats following physical exercise are likely to be related to the synaptic ultrastructural modification and the earlier emergence of LTP in contralateral CA3 region.
Moderate Exercise Combined with Enriched Environment Enhances Learning and Memory through BDNF/TrkB Signaling Pathway in Rats
  • L. Xu, Linna Zhu, Aiguo Chen
  • Biology, Psychology
    International journal of environmental research and public health
  • 2021
The data robustly demonstrate that the combination of TE + EE enhances learning and memory ability and upregulates the expression of both BDNF and TrkB in rats.
Physical Exercise and Spatial Training: A Longitudinal Study of Effects on Cognition, Growth Factors, and Hippocampal Plasticity
While substantial physical and spatial training gains were elicited in all trained groups, longitudinal transfer changes did not differ between these groups, and the results challenge the extrapolation from the findings reported in animals to young, healthy adults.
GABAergic Input Affects Intracellular Calcium Levels in Developing Granule Cells of Adult Rat Hippocampus
A novel molecular and electrophysiological mechanism, involving calcium-activated potassium channels (BK) and T-type voltage-dependent calcium channels, through which GABA fine-tunes intracellular calcium homeostasis in rat adult-born granule neurons early during their maturation might be instrumental in promoting newborn cell survival.
Physical exercise promotes proliferation and differentiation of endogenous neural stem cells via ERK in rats with cerebral infarction
The results indicated that physical exercise promoted proliferation and differentiation of NSCs, and led to improved neural function, and U0126, an inhibitor of ERK signaling, reversed the beneficial effects of exercise.
Neuroplasticity and Neuroprotective Effect of Treadmill Training in the Chronic Mouse Model of Parkinson's Disease
The view that physical activity may be neuroprotective even at a more advanced stage of PD and justify starting physical activity at any point of the disease is supported.
Increased protein expression levels of pCREB, BDNF and SDF-1/CXCR4 in the hippocampus may be associated with enhanced neurogenesis induced by environmental enrichment.
EE improved cognitive function, and increased the proliferation, differentiation and survival of newly‑formed neurons in the DG of adult rats; however, EE did not activate neurogenesis in the SVZ, which provides a theoretical basis to explain the beneficial effects of EE on healthy, adult rats.


Synaptogenesis in adult‐generated hippocampal granule cells is affected by behavioral experiences
Experiences involving physical activity contextualized in an exploring behavior affect synaptogenesis in adult‐generated cells and their early stages of maturation.
Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
An association between CREB and BDNF expression and cognitive function, such that animals who were the fastest learners and had the best recall showed the highest expression of BDNF and associated CREB mRNA levels, suggest a functional role for CREB under the control ofBDNF in mediating the exercise‐induced enhancement in learning and memory.
Environmental enrichment influences BDNF and NR1 levels in the hippocampus and restores cognitive impairment in chronic cerebral hypoperfused rats.
It is demonstrated for the first time that EE exposure restores cognitive impairment induced by CCH and up-regulates the decreased protein levels of BDNF and NR1.
Short‐term environmental enrichment, in the absence of exercise, improves memory, and increases NGF concentration, early neuronal survival, and synaptogenesis in the dentate gyrus in a time‐dependent manner
It is reported that rats housed in an enriched environment for 3 and 6 weeks (wk) displayed improved recognition memory, while rats enriched for 6 wk also displayed improved spatial and working memory, indicating a time‐dependent cognitive‐enhancing effect of environmental enrichment that is independent of physical activity.
BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2
Using transgenic embryos that overexpress BDNF under the control of the nestin promoter, it is shown that BDNF controls the emergence and robustness of spontaneous activity in embryonic hippocampal slices and dramatically increases spontaneous co-active network activity.
New neurons in the dentate gyrus are involved in the expression of enhanced long‐term memory following environmental enrichment
It is established that newborn cells in the dentate gyrus contribute to the expression of the promnesic effects of behavioural enrichment, and they provide further support for the idea that adult‐generated neurons participate in modulating memory function.
Running enhances neurogenesis, learning, and long-term potentiation in mice.
The results indicate that physical activity can regulate hippocampal neurogenesis, synaptic plasticity, and learning.