Physical exercise and environment exploration affect synaptogenesis in adult-generated neurons in the rat dentate gyrus: Possible role of BDNF

@article{Ambrogini2013PhysicalEA,
  title={Physical exercise and environment exploration affect synaptogenesis in adult-generated neurons in the rat dentate gyrus: Possible role of BDNF},
  author={Patrizia Ambrogini and Davide Lattanzi and Stefano Ciuffoli and Michele Betti and Mirco Fanelli and Riccardo Cuppini},
  journal={Brain Research},
  year={2013},
  volume={1534},
  pages={1-12}
}
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Synaptogenesis in adult‐generated hippocampal granule cells is affected by behavioral experiences
TLDR
Experiences involving physical activity contextualized in an exploring behavior affect synaptogenesis in adult‐generated cells and their early stages of maturation.
Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
TLDR
An association between CREB and BDNF expression and cognitive function, such that animals who were the fastest learners and had the best recall showed the highest expression of BDNF and associated CREB mRNA levels, suggest a functional role for CREB under the control ofBDNF in mediating the exercise‐induced enhancement in learning and memory.
Environmental enrichment influences BDNF and NR1 levels in the hippocampus and restores cognitive impairment in chronic cerebral hypoperfused rats.
TLDR
It is demonstrated for the first time that EE exposure restores cognitive impairment induced by CCH and up-regulates the decreased protein levels of BDNF and NR1.
Short‐term environmental enrichment, in the absence of exercise, improves memory, and increases NGF concentration, early neuronal survival, and synaptogenesis in the dentate gyrus in a time‐dependent manner
TLDR
It is reported that rats housed in an enriched environment for 3 and 6 weeks (wk) displayed improved recognition memory, while rats enriched for 6 wk also displayed improved spatial and working memory, indicating a time‐dependent cognitive‐enhancing effect of environmental enrichment that is independent of physical activity.
BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2
TLDR
Using transgenic embryos that overexpress BDNF under the control of the nestin promoter, it is shown that BDNF controls the emergence and robustness of spontaneous activity in embryonic hippocampal slices and dramatically increases spontaneous co-active network activity.
New neurons in the dentate gyrus are involved in the expression of enhanced long‐term memory following environmental enrichment
TLDR
It is established that newborn cells in the dentate gyrus contribute to the expression of the promnesic effects of behavioural enrichment, and they provide further support for the idea that adult‐generated neurons participate in modulating memory function.
Running enhances neurogenesis, learning, and long-term potentiation in mice.
TLDR
The results indicate that physical activity can regulate hippocampal neurogenesis, synaptic plasticity, and learning.
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