Physical evidence for distinct mechanisms of translational control by upstream open reading frames.

@article{Gaba2001PhysicalEF,
  title={Physical evidence for distinct mechanisms of translational control by upstream open reading frames.},
  author={Anthony Gaba and Zhong Wang and Thanuja Krishnamoorthy and Alan G Hinnebusch and Matthew S. Sachs},
  journal={The EMBO journal},
  year={2001},
  volume={20 22},
  pages={
          6453-63
        }
}
The Saccharomyces cerevisiae GCN4 mRNA 5'-leader contains four upstream open reading frames (uORFs) and the CPA1 leader contains a single uORF. To determine how these uORFs control translation, we examined mRNAs containing these leaders in cell-free translation extracts to determine where ribosomes were loaded first and where they were loaded during steady-state translation. Ribosomes predominantly loaded first at GCN4 uORF1. Following its translation, but not the translation of uORF4, they… CONTINUE READING

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