Physical environment modulates the behavioral responses induced by chemical stimulation of dorsal periaqueductal gray in mice

@article{CarvalhoNetto2006PhysicalEM,
  title={Physical environment modulates the behavioral responses induced by chemical stimulation of dorsal periaqueductal gray in mice},
  author={Eduardo Ferreira de Carvalho-Netto and Chris M. Markham and D. Caroline Blanchard and Ricardo L. Nunes‐de‐Souza and Robert J. Blanchard},
  journal={Pharmacology Biochemistry and Behavior},
  year={2006},
  volume={85},
  pages={140-147}
}
In order to investigate the relationship between behaviors elicited by chemical stimulation of the dorsal periaqueductal gray (dorsal PAG) and spontaneous defensive behaviors to a predator, the excitatory amino acid D,L-homocysteic acid (5 nmol in 0.1 micro l), was infused into the dorsal PAG and behavioral responses of mice were evaluated in two different situations, a rectangular novel chamber or the Mouse Defense Test Battery (MDTB) apparatus. During a 1-min period following drug infusion… 
Effects of intra-PAG infusion of ovine CRF on defensive behaviors in Swiss-Webster mice
TLDR
It is suggested that patterns of defensiveness in response to low intensity threat (RET) are more sensitive to intra-DPAG oCRF than those triggered by high intensity threats (MDTB).
Role of glutamate NMDA receptors and nitric oxide located within the periaqueductal gray on defensive behaviors in mice confronted by predator
TLDR
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TLDR
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TLDR
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5-HT2 receptor activation in the midbrain periaqueductal grey (PAG) reduces anxiety-like behaviour in mice
TLDR
5HT2C receptor populations within the midbrain PAG play an inhibitory role in plus-maze anxiety in mice, suggesting a role that in part depends upon neuroanatomical locus of action.
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TLDR
The present data offer a neuroanatomical basis for both intratectal axo-axonic/pre-synaptic and tecto-nigral axo -somatic opioid inhibition of GABAergic nigro-tectal neurons that modulate the dorsal midbrain neurons related to the organisation of fear-related emotional responses.
Blockade of 5-HT2 receptors in the periaqueductal grey matter (PAG) abolishes the anxiolytic-like effect of 5-HT1A receptor antagonism in the median raphe nucleus in mice
TLDR
5HT(2) receptor populations located within the midbrain PAG play a significant role in the reduction of anxiety observed following disinhibition of 5-HT neurons in the MRN, and this effect was completely blocked by intra-PAG pretreatment with an intrinsically-inactive dose of ketanserin.
Segregated Anatomical Input to Sub-Regions of the Rodent Superior Colliculus Associated with Approach and Defense
TLDR
Results indicate significantly more structures across the rat neuraxis are in a position to modulate defense responses evoked from SCm, and that neural mechanisms modulating SC-mediated defense or appetitive behavior are almost entirely segregated.
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