Physical dependence induced by opiate partial agonists in the rat

  title={Physical dependence induced by opiate partial agonists in the rat},
  author={P. S. McCarthy and G. J. Howlett},

Effects of ß-funaltrexamine on butorphanol dependence

The role of glutamate in physical dependence on opioids.

The present review will evaluate the interactions between kappa-opioid receptors and glutamate within the locus coeruleus (LC) during the development of opioid dependence and on expression of

μ- and δ-opioid receptor antagonists precipitate similar withdrawal phenomena in butorphanol and morphine dependence

Responses elicited following the use of selective μ- and δ-opioid receptor antagonists to precipitate withdrawal suggest that the role played by these receptors in mediation of the signs and symptoms of withdrawal do not differ greatly between butorphanol- and morphine-dependent rats.

Effects of morphine, naloxone, buprenorphine, butorphanol, haloperidol and imipramine on morphine withdrawal signs in cynomolgus monkeys

The data suggest buprenorphine exerts only opioid antagonistic activity and butorphanol exertsonly opioid agonistic activity over a wide range of doses studied in morphine-dependent cynomolgus monkeys.

Buprenorphine and carbamazepine as a treatment for detoxification of opiate addicts with multiple drug misuse: a pilot study

The hypothesis that buprenorphine/carbamazepine is more effective than oxazepam/carbazepine in rapid opioid detoxification in patients with additional multiple drug misuse is supported and both regimens were safe with no unexpected side effects.

Mood and affect during detoxification of opiate addicts: a comparison of buprenorphine versus methadone

The hypothesis that the combination of buprenorphine and carbamazepine leads to a better clinical outcome than does a combination of methadone and carbazepine in the detoxification of opioid addicts with additional multiple drug abuse is supported.

Activation profiles of opioid ligands in HEK cells expressing δ opioid receptors

The data produced can lead to elucidation of the complete activation profiles of several opioid ligands, leading to clarification of the mechanisms involved in physiological effects of these ligands at δ opioid receptors, and can be used as a basis for novel use of existing opioids ligands based on their pharmacology at ε opioid receptors.

Detoxifikation polytoxikomaner Patienten mit Buprenorphin Auswirkungen auf Affektivität, Angst und Entzugssymptomaik

An open-labeled, 21-day inpatient detoxification treatment was used to compare the short-term effects of a 10-day buprenorphineplus 19-day carbamazepine regimen to a 14-day oxazepam plus 19- day carbamazenine regimen during rapid detoxification from opioids and other abused drugs.



Induction of physical dependence on morphine, codeine and meperidine in the rat by continuous infusion.

  • D. Teiger
  • Biology
    The Journal of pharmacology and experimental therapeutics
  • 1974
Continuous infusion allowed the demonstration of primary physical dependence on codeine and meperidine by abrupt withdrawal as well as precipitated withdrawal and suppression of morphine abstinence by methadone, codeine or me peridine substitution in both weakly and strongly morphine-dependent rats.

In vitro models in the study of structure-activity relationships of narcotic analgesics.

Evidence has been adduced for the view that the morphiness receptor or receptors in the myenteric plexus of guinea pig ileum are very similar to the brain receptors that mediate the analgesic action

A comparison of heat and pressure analgesiometric methods in rats.

A simple pressure method is described, which does not suffer from certain of the disadvantages of these earlier techniques, and the results are compared with those obtained by radiant heat stimulation.

Buprenorphine: differential interaction with opiate receptor subtypes in vivo.

The mixed agonist-antagonist buprenorphine previously was shown to display a bell-shaped dose-response curve with peak agonistic (antinociceptive) opiate effects at approximately 0.5 mg/kg s.c., but these results are consistent with the hypothesis that noncompetitive autoinhibition occurs among the opiate receptor subtypes.