Physical dependence in baboons chronically treated with low and high doses of diazepam.

@article{Kaminski2003PhysicalDI,
  title={Physical dependence in baboons chronically treated with low and high doses of diazepam.},
  author={Barbara J. Kaminski and Christine A. Sannerud and Elise M Weerts and Richard J Lamb and Roland R Griffiths},
  journal={Behavioural pharmacology},
  year={2003},
  volume={14 4},
  pages={
          331-42
        }
}
Physical dependence on diazepam was evaluated in male baboons chronically treated with either low or high doses of diazepam. Baboons received either a single oral daily administration of a low dose (0.5 mg/kg per day) of diazepam (n=4) or continuous intragastric infusion of a high dose (20 mg/kg per day) of diazepam (n=7). Development of physical dependence during chronic dosing with 0.5 mg/kg per day diazepam was assessed at 2 and 4 weeks and then monthly, during 1-h behavioral observations… CONTINUE READING
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