Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation.

@article{Poltorak2000PhysicalCB,
  title={Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation.},
  author={Alexander Poltorak and Paola Ricciardi-Castagnoli and Stefania Citterio and Bruce Beutler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 5},
  pages={2163-7}
}
Some mammalian species show an ability to discriminate between different lipopolysaccharide (LPS) partial structures (for example, lipid A and its congener LA-14-PP, which lacks secondary acyl chains), whereas others do not. Using a novel genetic complementation system involving the transduction of immortalized macrophages from genetically unresponsive C3H/HeJ mice, we now have shown that the species-dependent discrimination between intact LPS and tetra-acyl LPS partial structures is fully… CONTINUE READING
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