Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.

Abstract

Multidrug resistance (MDR), typified by resistance to Vinca alkaloids and anthracyclines, is a well characterized experimental phenomenon that may have some clinical correlates. Verapamil, chloroquine, and related drugs have been shown previously to be capable of enhancing anticancer drug cytotoxicity in multi-drug-resistant cells, but the mechanism(s) by… (More)

Topics

Cite this paper

@article{Zamora1988PhysicalchemicalPS, title={Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.}, author={J. A. Moreno Zamora and Harriet Pearce and Werner Beck}, journal={Molecular pharmacology}, year={1988}, volume={33 4}, pages={454-62} }