Physical characterization and macrophage cell uptake of mannan-coated nanoparticles.

  title={Physical characterization and macrophage cell uptake of mannan-coated nanoparticles.},
  author={Zhengrong Cui and Cheng-Hsuan Hsu and Russell J. Mumper},
  journal={Drug development and industrial pharmacy},
  volume={29 6},
Previously, we reported on a cationic nanoparticle-based DNA vaccine delivery system engineered from warm oil-in-water microemulsion precursors. In these present studies, the feasibility of lyophilizing the nanoparticles and their thermal properties were investigated. Also, the binding and uptake of the nanoparticles by a macrophage cell line were studied. The nanoparticles (prior to pDNA coating) were freeze-dried with lactose or sucrose as cryoprotectants. The stability of lyophilized… CONTINUE READING


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