Physical characteristics and aerosol performance of naringin dry powders for pulmonary delivery prepared by spray-drying.

@article{Sansone2009PhysicalCA,
  title={Physical characteristics and aerosol performance of naringin dry powders for pulmonary delivery prepared by spray-drying.},
  author={Francesca Sansone and Rita Patrizia Aquino and Pasquale Del Gaudio and P. -E. Colombo and Paola Russo},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2009},
  volume={72 1},
  pages={206-13}
}
The aim of the present work was to develop dry powders containing naringin for a direct administration to the lung to combat oxidative stress. Naringin microparticles were prepared by spray-drying the neat flavonoid (2-5% w/v) from different water/ethanol co-solvents. The spray-dried powders were characterised for morphology, density, particle size distribution, residual humidity, crystallinity, solubility, thermal behaviour and respirable fraction. The fine fraction of the powders was measured… CONTINUE READING

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