Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma.

@article{Ramsey2011PhysicalAO,
  title={Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma.},
  author={Matthew R. Ramsey and Lei He and Nicole Forster and Benjamin Ory and Leif W. Ellisen},
  journal={Cancer research},
  year={2011},
  volume={71 13},
  pages={
          4373-9
        }
}
Squamous cell carcinoma (SCC) is a treatment-refractory subtype of human cancer arising from stratified epithelium of the skin, lung, esophagus, oropharynx, and other tissues. A unifying feature of SCC is high-level expression of the p53-related protein p63 (TP63) in 80% of cases. The major protein isoform of p63 expressed in SCC is ΔNp63α, an N-terminally truncated form which functions as a key SCC cell survival factor by mechanisms that are unclear. In this study, we show that ΔNp63… CONTINUE READING

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