Physical and mechanical regulation of macrophage phenotype and function

  title={Physical and mechanical regulation of macrophage phenotype and function},
  author={Frances Y. McWhorter and Chase T. Davis and Wendy F Liu},
  journal={Cellular and Molecular Life Sciences},
Macrophages are tissue-resident immune cells that play a critical role in maintaining homeostasis and fighting infection. In addition, these cells are involved in the progression of many pathologies including cancer and atherosclerosis. In response to a variety of microenvironmental stimuli, macrophages can be polarized to achieve a spectrum of functional phenotypes. This review will discuss some emerging evidence in support of macrophage phenotypic regulation by physical and mechanical cues… CONTINUE READING

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