Physical and functional interactions between Escherichia coli MutY and endonuclease VIII.

@article{Lu2006PhysicalAF,
  title={Physical and functional interactions between Escherichia coli MutY and endonuclease VIII.},
  author={A. Lili Lu and Chih-Yung Sean Lee and Lina Li and Xianghong Li},
  journal={The Biochemical journal},
  year={2006},
  volume={393 Pt 1},
  pages={
          381-7
        }
}
Both GO (7,8-dihydro-8-oxoguanine) and hoU (5-hydroxyuracil) are highly mutagenic because DNA polymerase frequently misincorporates adenine opposite these damaged bases. In Escherichia coli, MutY DNA glycosylase can remove misincorporated adenine opposite G or GO on the template strand during DNA replication. MutY remains bound to the product that contains an AP (apurinic/apyrimidinic) site. Endo VIII (endonuclease VIII) can remove oxidized pyrimidine and weakly remove GO by its DNA glycosylase… CONTINUE READING

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