Physical and functional interaction of the HECT ubiquitin-protein ligases E6AP and HERC2.

@article{Khnle2011PhysicalAF,
  title={Physical and functional interaction of the HECT ubiquitin-protein ligases E6AP and HERC2.},
  author={Simone K{\"u}hnle and Ulrike Kogel and Sandra Glockzin and Andreas Marquardt and Aaron Ciechanover and Konstantin T. Matentzoglu and Martin Scheffner},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 22},
  pages={19410-6}
}
Deregulation of the ubiquitin-protein ligase E6AP contributes to the development of the Angelman syndrome and to cervical carcinogenesis suggesting that the activity of E6AP needs to be under tight control. However, how E6AP activity is regulated at the post-translational level under non-pathologic conditions is poorly understood. In this study, we report that the giant protein HERC2, which is like E6AP a member of the HECT family of ubiquitin-protein ligases, binds to E6AP. The interaction is… CONTINUE READING