Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF.

@article{Dai2012PhysicalAF,
  title={Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF.},
  author={Mu-Shui Dai and Kishore B Challagundla and X. L. Sun and Lakshmi Reddy Palam and S. X. Zeng and Ronald C Wek and Hua Lu},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 21},
  pages={17120-9}
}
The ARF tumor suppressor protein activates p53 in response to oncogenic stress, whereas ribosomal protein L11 induces p53 following ribosomal stress. Both proteins bind to central, albeit non-overlapping, regions of MDM2 and suppress MDM2 activity toward p53. However, it is not known whether the two pathways are functionally connected. Here we show that ARF directly binds to L11 in vitro and in cells, which then forms a complex with MDM2 and p53. L11 collaboratively enhances ARF-induced p53… CONTINUE READING

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