Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1.

@article{Hegde2008PhysicalAF,
  title={Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1.},
  author={Muralidhar L Hegde and Corey A. Theriot and Aditi Das and Pavana M Hegde and Zhigang Guo and Ronald K Gary and Tapas K Hazra and Binghui Shen and Sankar Mitra},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 40},
  pages={
          27028-37
        }
}
The S phase-specific activation of NEIL1 and not of the other DNA glycosylases responsible for repairing oxidatively damaged bases in mammalian genomes and the activation of NEIL1 by proliferating cell nuclear antigen (PCNA) suggested preferential action by NEIL1 in oxidized base repair during DNA replication. Here we show that NEIL1 interacts with flap endonuclease 1 (FEN-1), an essential component of the DNA replication. FEN-1 is present in the NEIL1 immunocomplex isolated from human cell… CONTINUE READING
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