Physical and functional interaction between p72(syk) and erythropoietin receptor.

  title={Physical and functional interaction between p72(syk) and erythropoietin receptor.},
  author={V{\'e}ronique Duprez and Ulrich Blank and Stany Chr{\'e}tien and Sylvie Gisselbrecht and Patrick Mayeux},
  journal={The Journal of biological chemistry},
  volume={273 51},
Erythropoietin (Epo) regulates the proliferation and differentiation of erythroid cells through interaction with a cell surface receptor (EpoR) that belongs to the cytokine receptor family. The Jak2 tyrosine kinase was previously shown to bind to the EpoR, to be activated upon Epo stimulation, and to play a critical role in Epo-induced proliferation. However, little is known about the role of other tyrosine kinases in Epo signaling. In this paper, we examined whether Syk was involved in EpoR… CONTINUE READING
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