Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence.

  title={Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence.},
  author={Nadine Martin and Moussa Benhamed and Karim Nacerddine and Maud D Demarque and Maarten van Lohuizen and Anne Dejean and Oliver Bischof},
  journal={The EMBO journal},
  volume={31 1},
Cellular senescence acts as a potent barrier for tumour initiation and progression. Previous studies showed that the PML tumour suppressor promotes senescence, although the precise mechanisms remain to be elucidated. Combining gene expression profiling with chromatin-binding analyses and promoter reporter studies, we identify TBX2, a T-box transcription factor frequently overexpressed in cancer, as a novel and direct PML-repressible E2F-target gene in senescence but not quiescence. Recruitment… CONTINUE READING


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