Physical and functional interaction between DDB and XPA in nucleotide excision repair

  title={Physical and functional interaction between DDB and XPA in nucleotide excision repair},
  author={Mitsuo Wakasugi and Hiromi Kasashima and Yuko Fukase and Mayumi Imura and Rika Imai and Saki Yamada and J. E. Cleaver and Tsukasa Matsunaga},
  booktitle={Nucleic acids research},
Damaged DNA-binding protein (DDB), consisting of DDB1 and DDB2 subunits recognizes a wide spectrum of DNA lesions. DDB is dispensable for in vitro nucleotide excision repair (NER) reaction, but stimulates this reaction especially for cyclobutane pyrimidine dimer (CPD). Here we show that DDB directly interacts with XPA, one of core NER factors, mainly through DDB2 subunit and the amino-acid residues between 185 and 226 in XPA are important for the interaction. Interestingly, the point mutation… CONTINUE READING


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